US-based commercial-stage medical technology firm Centinel Spine has received the US Food and Drug Administration (FDA) approval for two-level use of its prodisc C Nova cervical total disc replacement system.
The regulatory clearance permits the motion-preserving device to be implanted across two levels in the cervical spine.
Following this decision, Centinel Spine now offers three distinct cervical total disc replacement devices cleared for both single- and two-level applications: prodisc C Nova, prodisc C SK, and prodisc C Vivo.
The other two systems, prodisc C SK and prodisc C Vivo, secured FDA approval for two-level indications in October 2025.
Centinel Spine stated that having multiple approved designs supports its Match-the-Disc approach, allowing surgeons to select or combine different implants according to patient anatomy at each treated level.
Centinel Spine CEO Steve Murray said: “This approval represents another important advancement for our Match-the-Disc portfolio.
“With three distinct prodisc cervical devices now approved for both one- and two-level use, we continue to expand our cervical portfolio and advance our strategy of providing multiple implant designs to address differences in patient anatomy and disease advancement.
“The two-level approval of prodisc C Nova represents another important milestone in the continued evolution of our Match-the-Disc approach.”
The prodisc C Nova is currently available in the US on a limited-release basis. The implant has been in clinical use outside the US since 2009.
Engineered to match specific vertebral structures, the prosthesis features flat endplates with low-profile keels and incorporates the prodisc CORE technology that provides the kinematic foundation for the broader product platform.
Centinel Spine concentrates exclusively on total disc replacement technologies for both cervical and lumbar spinal indications.
The company positions motion-preserving devices as an alternative to traditional spinal fusion procedures that permanently eliminate mobility between vertebrae.
According to the firm, its anatomical implant range is developed to preserve natural movement and address long-term quality of life in patients suffering from chronic neck and back pain.
