The University of Nottingham in the UK has announced a collaboration with Italy’s Aboca and specialists from the University’s Sir Peter Mansfield Magnetic Resonance Imaging Centre for a feasibility study on magnetic resonance imaging (MRI) visualisation of natural gastrointestinal therapies.
The research seeks to use MRI technology to observe the protective film created by the NeoBianacid substance-based medical device on the oesophagus and stomach mucosa in humans.
This project aims to advance knowledge about the mechanisms through which natural therapies function within the human body.
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NeoBianacid is described as a medical device comprising 100% natural and biodegradable substances.
The product contains Poliprotect, which is a patented complex derived from plant polysaccharides sourced from Althaea officinalis, Malva sylvestris, and aloe vera, combined with minerals such as nahcolite and limestone, as well as a flavonoid fraction from Matricaria recutita and Glycyrrhiza glabra.
A clinical trial, with findings published in the American Journal of Gastroenterology in July 2023, indicated that NeoBianacid was non-inferior to omeprazole (20mg) in patients experiencing heartburn and epigastric burning who did not have gastroduodenal lesions or erosive oesophagitis.
The current MRI study intends to show how Aboca’s medical device forms its protective layer in vivo.
Researchers seek to confirm that MRI can serve as a non-invasive technique to monitor the formation and persistence of NeoBianacid’s protective layer on the mucosa of the stomach and oesophagus in healthy volunteers, potentially supporting future investigations into similar medical devices.
University of Nottingham School of Medicine’s Dr Maura Corsetti said: “This is the first time that MRI has been used to assess the effect of coating a natural product on the upper gastrointestinal tract and represents an important step towards a better understanding of how natural therapies work within the human body.”
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